IDX-1197 is a potent PARP inhibitor that prevents the repair of DNA single-strand breaks (SSB) and promote the conversion of SSB to double-stranded breaks (DSB), which ultimately leads to synthetic lethality in cancer cells. IDX-1197 is under clinical development targeting multiple solid tumors as a monotherapy (including maintenance, NCT04174716) and for combination with other anti-cancer agents.
Press Release

Development of IDX-1197, a novel, selective, and highly potent PARP inhibitor


A comparative preclinical study of PARP inhibitors demonstrates superb properties for IDX-1197